Democracy Under Attack time.comJAN. 18 / JAN. 25, 2021 DOUBLE ISSUEResults may vary. OPDIVO ® + YERVOY ® is not approved for patients younger than 18 years of age.In a study of newly diagnosed advanced NSCLC patients, half of those on OPDIVO + YERVOY were alive at 17.1 months versus 14.9 months on platinum-based chemotherapy.For certain adults with newly diagnosed metastatic non-small cell lung cancer (NSCLC) that tests positive for PD-L1 =A CHANCE FOR MORE SNUGGLY SUNDAYS A Chance to Live Longer™ THE 1ST AND ONL Y FDA-APPROVED CHEMO-FREE COMBINATION OF 2 IMMUNOTHERAPIES THAT WORKS DIFFERENTL Y Indication & Important Safety Information for OPDIVO (nivolumab) + YERVOY (ipilimumab) Only your healthcare professional knows the specifics of your condition and how OPDIVO in combination with YERVOY may fit into your overall therapy. The information below does not take the place of talking with your healthcare professional, so talk to them if you have any questions. What are OPDIVO and YERVOY? OPDIVO and YERVOY are prescription medicines used to treat people with a type of advanced stage lung cancer called non-small cell lung cancer (NSCLC). OPDIVO may be used in combination with YERVOY as your first treatment for NSCLC when your lung cancer has spread to other parts of your body (metastatic) and your tumors are positive for PD-L1, but do not have an abnormal EGFR or ALK gene. It is not known if OPDIVO and YERVOY are safe and effective when used in children younger than 18 years of age. What is the most important information I should know about OPDIVO and YERVOY? OPDIVO and YERVOY are medicines that may treat certain cancers by working with your immune system. OPDIVO and YERVOY can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become serious or life-threatening and can lead to death and may happen anytime during treatment or even after your treatment has ended. You may have more than one of these problems at the same time. Some of these problems may happen more often when OPDIVO is used in combination with YERVOY. Call or see your healthcare provider right away if you develop any new or worse signs or symptoms, including • Lung problems: new or worsening cough; shortness of breath; chest pain • Intestinal problems: diarrhea (loose stools) or more frequent bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; severe stomach-area (abdominal) pain or tenderness • Liver problems: yellowing of your skin or the whites of your eyes; severe nausea or vomiting; pain on the right side of your stomach area (abdomen); dark urine (tea colored); bleeding or bruising more easily than normal • Hormone gland problems: headaches that will not go away or unusual headaches; eye sensitivity to light; eye problems; rapid heartbeat; increased sweating; extreme tiredness; weight gain or weight loss; feeling more hungry or thirsty than usual; urinating more often than usual; hair loss; feeling cold; constipation; your voice gets deeper; dizziness or fainting; changes in mood or behavior, such as decreased sex drive, irritability, or forgetfulness • Kidney problems: decrease in the amount of urine; blood in your urine; swelling in your ankles; loss of appetite • Skin problems: rash; itching; skin blistering or peeling; painful sores or ulcers in mouth or nose, throat, or genital area • Eye problems: blurry vision, double vision, or other vision problems; eye pain or redness Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with OPDIVO and YERVOY. Call or see your healthcare provider right away for any new or worsening signs or symptoms, which may include: • Chest pain; irregular heartbeat; shortness of breath; swelling of ankles • Confusion; sleepiness; memory problems; ch