ISO/TS TECHNICAL SPECIFICATION 21623 First edition 2017-11 Workplace exposure - Assessment of dermal exposure to nano- objects and their aggregates and agglomerates (NOAA) Exposition sur les lieuxdetravail-EvaluationdeI'exposition cutanéeaux nano-objets et d leurs agregats et agglomérats (NOAA) Referencenumber IS0/TS21623:2017(E) ISO @ ISO 2017 IS0/TS21623:2017(E) COPYRIGHTPROTECTEDDOCUMENT @ IS0 2017, Published in Switzerland All rights reserved. Unless otherwise specified, no part of this publication may be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on the internet or an intranet, without prior written permission. Permission can be requested from either ISO at the address below or ISo's member body in the country of the requester. ISO copyright office Ch.de Blandonnet 8.CP 401 CH-1214 Vernier, Geneva, Switzerland Tel. +41 22 749 01 11 Fax +41 22 749 09 47 copyright@iso.org www.iso.org ii IS02017-Allrights reserved IS0/TS21623:2017(E) Contents Page Foreword iv Introduction A 1 Scope 1 2 Normativereferences .1 3 Terms and definitions .1 4 DermalexposuretoNOAAEvidenceandexposureroutes 4 4.1 General 4 4.2 Source domains 4 4.3 Exposureroutes 5 5 Stepwise approach for assessment of dermal exposure to NoAA 6 5.1 6 General 5.2 Step 1: Desk evaluation. 7 5.2.1 Step 1A: Evaluation of toxicological hazard based on NOAA composition 7 5.2.2 Step1B: Screening forpotential risks associated with dermal exposureto insoluble (non-flexible) NOAA 8 5.2.3 Step 1C: Screeningfor potential risks associated with dermal exposure based on job title 10 5.3 Step2: Observation of potential for dermal exposure .11 5.4 Step3:Additional observation ofworkerbehaviour. .11 5.5 Step4:QuantificationofNOAA 11 5.6 Step5:Evaluationand review .12 Annex A (informative) Industries associated with use of nanomaterials or nano- enabledproducts .13 AnnexB (informative)Howtodetermineskindisruption? .16 AnnexC (informative)DeRmalExposureAssessmentMethod(DREAM) ..18 AnnexD (informative)Inadvertent ingestion exposure .24 AnnexE (informative)Exploring dermal exposuremeasurements ofnanoparticles .27 Bibliography .31 @ IS0 2017 - All rights reserved iii